The first part of the essay briefly outlines the figures of Girolamo I Colonna, Filippo I, Prince of Paliano, and Anna Tomacelli. In 1639-1640, the Roman cardinal – one of the first refined collectors of the Colonna house, partial to the painting of important Bolognese masters and their students – approached to skilled masters of Sicilian Baroque for the creation of a precious altar furniture piece in copper and coral, composed of six candlesticks and a cross. The unpublished correspondence between Girolamo I and his brother Marcantonio V, a point of reference in Sicily at that time for the Colonna family for having married the rich Sicilian heiress Isabella Gioeni, and intermediary for the creation of the artefacts, contains interesting notes on their execution. The important works produced by Trapani coral workers active in Palermo, destined in the will of the illustrious prelate to the Sanctuary of Our Lady of Good Counsel in Genazzano, are compared with the contemporary Sicilian production, providing unpublished evidence of the art of coral in Sicily.